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Explanation
This comic features a person screaming "AAAAAAAAA" in the first panel in what appears to be distress or existential anguish. In the second panel, another person observes, "I see you're constantly screaming. Have you tried meditation?" The third panel shows the screamer sitting cross-legged in a meditation pose, seemingly calm, with the word "INTERESTING" appearing to indicate a moment of thoughtful reflection.
The punchline comes in the fourth panel, labeled "LATER," where the person is now meditating in proper form but continues to scream "AAAAAAAAA" -- having simply incorporated the screaming into their meditation practice rather than replacing it.
The joke satirizes the common advice to "just try meditation" as a cure-all for anxiety, stress, or existential dread. Rather than meditation solving the underlying problem, the person has merely merged their anguish with their mindfulness practice. It pokes fun at the superficial wellness culture suggestion that meditation is a simple fix for deep-seated distress, while also being an absurdist visual gag about someone screaming while sitting in a perfectly calm lotus position.