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Explanation
This comic references the famous quote attributed to Ernest Rutherford: "All science is either physics or stamp collecting." Rutherford, a physicist who won the Nobel Prize in Chemistry, was dismissing all non-physics sciences as mere taxonomy -- just cataloging and categorizing things rather than uncovering fundamental laws.
The top panel presents the quote with a caricature of Rutherford, setting up the premise. Below, the comic shows "History's Most Important Scientist" (presumably meant to be a physicist like Newton or Einstein), and when asked "Darwin, what are you doing?" the scientist responds that he is "staring at this worm" and has been doing so for months, asking "Has it done anything? ...Almost."
The humor lies in the ironic juxtaposition. The comic first presents physics' claim to superiority over all other sciences, then immediately undercuts it by showing one of the most important scientists in history -- Charles Darwin -- engaged in what is essentially the most extreme version of "stamp collecting" imaginable: literally watching a single worm do nothing for an extended period. Darwin famously did spend years studying earthworms, publishing The Formation of Vegetable Mould Through the Action of Worms in 1881. The joke is that this patient, unglamorous observation led to some of the most revolutionary ideas in the history of science, making Rutherford's dismissal look foolish. The comic champions the slow, observational work that physicists deride while also finding genuine comedy in just how boring Darwin's research methods could appear from the outside.