bigger
Explanation
The comic features a conversation between a human woman and an alien blob-like creature about brain size and intelligence. The woman asks why evolution does not just give humans bigger brains, since they are limited by the size of the birth canal. The alien explains that human brains do not actually work the way humans think -- neural evolution does not always favor bigger brains. The alien describes how human cognition builds up from basic pattern recognition to associations to predictions to complex models using combined word models, all of which do not require a proportionally larger brain.
When asked what the woman would do if her neocortex were a quarter bigger, she honestly admits she would "think about butts unceasingly until I die of thirst" -- a candid acknowledgment that more brain power would likely be channeled toward base desires rather than higher thinking. The alien confirms this with "Bingo," and explains that the only way to transcend human intelligence would be to build a mind without desires, but since the engineers building it are humans, they would just program it to do laundry in sexy underwear.
The final exchange delivers the real punchline: the human asks if humans are the absolute pinnacle of intelligence, and the alien replies, "In the same sense that roaches are the pinnacle of survival." This is a pointed commentary on how intelligence, like survival, is not a single ladder with a clear top. The comic satirizes human hubris about intelligence while making the scientific point that bigger brains do not automatically mean smarter beings, and that human cognitive limitations are as much about motivation and desire as about raw processing power.