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Explanation
The Joke
The comic begins with a scientist marveling at the human brain's capabilities: the ability to use language, build tools, create mathematics, and manipulate symbols in ways that far outstrip any other known creature. After years and years of new opinion research, we now know that these incredible faculties can be completely overridden -- a man on a phone tells the scientist he should not believe scientists, and that he should trust his gut feeling instead, because "they're wrong."
The scientist's defeated response in the final panel -- "So pristine. So perfect." -- is delivered with visible anguish, marveling at the irony: the very brain sophisticated enough to develop science is also sophisticated enough to convince itself that science is wrong, based on nothing but a gut feeling from a stranger on a phone.
The Humor
The humor lies in the painful irony of the setup and punchline. The comic first establishes how extraordinary the human brain is -- and then immediately demonstrates how that extraordinary brain can be completely short-circuited by a random person's unsupported opinion. The phrase "so pristine, so perfect" reads as darkly sarcastic: the scientist is sarcastically admiring the blank, untouched-by-evidence quality of the caller's mind. The title "blank" likely refers to the blank-slate quality of the caller's reasoning -- unmarked by any actual evidence or critical thinking. The comic captures a common frustration among scientists and experts: the more evidence accumulates, the more some people dig into gut-feeling-based contrarianism.