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Explanation
The Joke
A patient tells his therapist, "I just don't think these antidepressants are the right fit for me, doc." The therapist asks if he is worried they have the wrong dosage or that they are interacting badly with his personality. The patient replies, "No, it's just that since my problems are caused entirely by pop culture, I feel like they should be branded." He means that because his depression stems from cultural consumption (media, trends, etc.) rather than biochemistry, his medication should have trendy branding to match.
The final panel reveals the result: the patient is now happily taking pills from a bottle that looks like a branded collectible, labeled with pop-culture-style graphics. The therapist notes, "They're in three collectible bottles," and "The pills are shaped like tiny Groots" -- a reference to the popular Marvel character. The patient responds enthusiastically that they "taste really good."
The Humor
The comic satirizes the intersection of consumer culture, mental health, and branding. It pokes fun at the idea that people are so thoroughly immersed in pop culture that even their medical treatment needs to be "on brand." The specific details -- collectible bottles, pills shaped like Groot -- lampoon how everything in modern life gets the merchandising treatment. There is also a subtle dig at the pharmaceutical industry, which does in fact heavily brand and market its products, and at patients who might prioritize aesthetics and branding over actual medical efficacy.
References
Groot is a character from Marvel's "Guardians of the Galaxy" franchise, known for being a sentient tree creature. The reference to "collectible bottles" parodies the widespread practice of creating limited-edition collectible packaging for consumer products.