clockmaker
Explanation
The Joke
The comic uses the classic "Clockmaker" metaphor for God -- the idea from 18th-century deism that God created the universe like a watchmaker who builds a clock, sets it in motion, and then steps back. A person prays "Dear God..." and God interrupts to explain that he just set the universe in motion and doesn't make changes. When the person asks who they should talk to, God suggests "her" -- referring to evolution, "the only one who gets things done." But evolution, personified as a woman, can't really have a conversation because she works extremely slowly, and is "busy turning a cow into a fish" (a humorous oversimplification of how evolution works).
The person tries to address evolution directly ("Dear Evolution...") but she responds "Can't talk. Busy." She confirms she is "slowly turning a cow into a fish," and the person reacts with "That's it? Yeah... slowwwwwwly." The joke is that evolution does work, but on timescales completely useless for anyone seeking immediate help.
The Humor
The comic cleverly plays with the theological problem of divine intervention by taking the deist position to its logical comedic extreme. If God truly is a hands-off clockmaker, then your only recourse for change is evolution -- which technically does reshape life, but over millions of years and with no intentionality or ability to take requests. The absurdity of trying to pray to evolution highlights how unsatisfying the deist answer is for someone who actually wants help with their problems.
The detail about turning "a cow into a fish" is deliberately backwards from how we typically think of evolution (life moved from sea to land), making it both funnier and a commentary on how evolution doesn't have a direction or goal -- it just produces change over vast timescales.
The votey panel shows God (or a figure) saying "Now FAST!" -- suggesting an impatient desire to speed up the glacially slow process of evolution, which of course is impossible.
References
The Clockmaker or Watchmaker analogy is a classical argument in the philosophy of religion, most famously articulated by William Paley in his 1802 work "Natural Theology." Deism, popular among Enlightenment thinkers like Voltaire and some of America's Founding Fathers, holds that God created the universe but does not intervene in its operation. The comic contrasts this with the theory of evolution by natural selection, proposed by Charles Darwin, which explains biological change through undirected natural processes operating over millions of years.