co-op
Explanation
This comic shows a group of people looking up at a giant screen or sky displaying the message: "HOLY LIVING S**T. YOU GUYS, THIS WAS SUPPOSED TO BE COOPERATIVE MODE. WHAT WERE YOU THINKING?" The caption reads: "We found out the universe was a simulation in the worst way possible."
The joke imagines that humanity discovers it's living in a simulation -- a popular philosophical concept (the simulation hypothesis) -- but the revelation comes in the form of an exasperated game administrator scolding the players. The humor is that the simulation was meant to be a cooperative game, but humanity has been playing it competitively, fighting and exploiting each other instead of working together. The administrator's incredulous, profanity-laden reaction suggests that humanity's behavior is so far from the intended cooperative gameplay that the simulation runners are baffled and frustrated. It's a commentary on humanity's failure to cooperate despite presumably having every reason to, reframed through the lens of video game culture where "co-op mode" means players are supposed to work together.