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Explanation
The Joke
The comic contrasts two situations involving the same woman. In the left panel, labeled "When someone tells you that your social views are equivalent to murder," she responds calmly with "Well, we all have opinions, buddy" -- completely unfazed by an extreme accusation. In the right panel, labeled "When a dentist tells you that you should floss more," she is on her knees, wailing "I AM GARBAGE! HUMAN GARBAGE!" -- completely devastated by mild, routine health advice.
The Humor
The joke captures a deeply relatable human irrationality: we can shrug off the most extreme moral condemnations from strangers or people on the internet, but the mildest professional criticism -- especially from a dentist about flossing -- cuts straight to the core of our self-worth. The comic highlights how our emotional reactions are often wildly disproportionate to the actual severity of the criticism. Being called morally equivalent to a murderer is objectively far worse than being told to floss, yet the dentist's gentle suggestion triggers a complete emotional breakdown. This resonates because almost everyone has experienced the particular shame of sitting in a dentist's chair and being told they are not flossing enough, and feeling like a terrible person despite knowing it is trivially fixable.