digest
Explanation
This comic is about the strangeness of food preferences when you actually think about what foods are. One character offers another some cheese, and the second character enthusiastically responds: "Oh my God, I love pre-digested food!"
The first character is taken aback, and the cheese-lover explains that "most food is a scary way to describe my precious garbage" -- pointing out that cheese is essentially "solidified, bacterially processed milk" or something along those lines. The conversation continues with the observation that food in general involves processes that sound disgusting when described scientifically: fermentation, bacterial cultures, enzymatic breakdown, and so on.
When something is described as "a liquidy byproduct of microbial digestion of a bovine secretion," it sounds revolting -- but that's just cheese. The other character says "that's just weird," to which the reply is: "It's exclusively composed of alcohol and cheese" -- suggesting that many beloved foods and drinks are, when you strip away the familiar names, the products of controlled decomposition and microbial activity.
The comic highlights the cognitive dissonance between how much we enjoy certain foods and how horrifying they sound when described in clinical or biological terms. The humor comes from the contrast between the visceral disgust of the descriptions and the everyday normalcy of the foods being described. It's a classic SMBC move: taking something completely mundane, describing it with scientific accuracy, and revealing it to be profoundly weird.