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Explanation
The Joke
A person asks "You know why dogs sniff each other's anuses? It's gross." Another person responds with a thought experiment: "Imagine you could find out someone's economic status, social status, health, relationship status, and basically everything you wanted" just by performing a similar act. The first person is appalled, but the second person continues: "Status update: I was gonna say something but then I noticed a problem in the human genome."
The final panel shows a dog looking up at a person with the observation that "dogs think the fact that humans still use their eyes for social information is adorable."
The Humor
The comic flips the common human reaction of disgust at dog behavior by reframing it as a matter of informational efficiency. When you think about it from a pure information-gathering standpoint, dogs' ability to learn everything about another individual from a quick sniff is remarkably efficient compared to the elaborate, time-consuming, and often unreliable ways humans gather social information (social media stalking, conversation, observation). The joke inverts the typical human-superiority framing: instead of dogs being gross, humans are the ones with the inferior social-information technology. The final panel completes the reversal by having the dog pity humans for their primitive reliance on visual cues, the same way humans pity dogs for their "gross" sniffing behavior.