enormous
Explanation
The comic shows a group of women with their breasts prominently displayed (pixelated/censored in the image), accompanied by a fake network disclaimer: "NBC wishes to assure its viewership that these enormous jiggling breasts are fully compliant with applicable FCC guidelines."
The caption below reads: "If the government declares trans women are men, the opportunities are enormous."
The joke operates on a satirical what-if scenario: if anti-trans legislation officially reclassifies trans women as men, then by the government's own logic, their bodies would be classified as male bodies. Since FCC broadcast indecency rules in the United States apply specifically to the display of female nudity (male chests are permitted on broadcast television), this reclassification would paradoxically mean that trans women's breasts could be shown freely on TV, since they would officially belong to "men." The word "enormous" in the title works as a double entendre, referring both to the business opportunities and to the breasts depicted.
The humor mechanism is reductio ad absurdum: Weinersmith takes anti-trans policies to their logical conclusion and reveals an absurd consequence. The comic also highlights the arbitrary nature of FCC censorship standards, which treat anatomically similar body parts differently based solely on the gender of the person they belong to. The joke implicitly mocks both anti-trans legislation and puritanical broadcast standards in a single stroke.
The hover text ("Ironically, I had to censor this due to running ads, but... one day...") adds a meta layer, with Weinersmith noting that he himself had to censor the image for commercial reasons, the very same kind of content policing the comic satirizes.