Fermi Paradox
Explanation
This comic offers a darkly humorous "solution" to the Fermi Paradox.
The Fermi Paradox is the apparent contradiction between the high probability that extraterrestrial civilizations exist (given the vast size and age of the universe) and the lack of evidence for them. A person prays to God asking for the solution to the Fermi Paradox. God responds: "You're in Hell." The explanation is that human civilization did make first contact with aliens, fought a nuclear war, and ended up in Hell. The people in Hell were the first ones past the gate, meaning they arrived before the aliens -- humanity just hasn't figured out its situation yet.
In the final panels, the man protests that Hell "honestly doesn't seem so bad," and God replies: "I keep making it worse and you things keep adjusting." This adds another layer to the joke -- it suggests that the gradually worsening state of the world (or at least how people perceive it) might literally be an ever-escalating Hell, and humanity's remarkable ability to normalize terrible conditions prevents us from realizing it.
The comic plays on multiple themes Zach Weinersmith frequently explores: the Fermi Paradox, theology, human adaptability, and the idea that our reality might be worse than we think but we've simply acclimated to it.