fuzz
Explanation
This comic shows a flying saucer near Earth, with an alien speaking from the ship. The alien says: "Ugh, these. We bred them to be larger and not have all the fuzz, and now they ship well but taste like nothing. Just leave them alone."
The caption reads: "Humans are the Red Delicious of the galaxy."
The joke works on multiple levels. Red Delicious apples are perhaps the most well-known example of agricultural breeding gone wrong. Originally a flavorful apple variety, decades of selective breeding optimized them for appearance (bright red color, iconic shape), durability during shipping, and shelf life -- at the complete expense of taste and texture. The result is an apple that looks perfect but is mealy and flavorless, widely regarded as one of the worst-tasting apple varieties despite being one of the most commercially successful.
The comic imagines that aliens did the same thing to humans -- breeding us to be larger (compared to our primate ancestors, who were indeed smaller and hairier) and removing "the fuzz" (body hair), resulting in beings that "ship well" (are durable and widespread) but "taste like nothing" (are bland or uninteresting). The aliens' dismissive attitude -- "just leave them alone" -- mirrors how many people now feel about Red Delicious apples: not worth the effort.
There's also an implicit joke about the ancient astronaut theory -- the idea that aliens may have guided human evolution -- but here it's reframed as a mundane agricultural project that the aliens have since lost interest in because the product turned out disappointing. The comic humorously deflates human self-importance by comparing us to a mediocre piece of fruit.