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Explanation
This comic depicts a person arriving at the gates of Heaven, only to find that the admission criteria have changed dramatically. Saint Peter (or a similar gatekeeper) explains that the old rule-based system -- "never killed anyone, never performed any exotic activities involving the anus" -- has been replaced because it was too easy to game.
The new system evaluates people holistically. The gatekeeper notes that while the applicant is "good on the usual criteria," when they factor in the full context of history, it turns out that a different scoring system would have been better at identifying truly good people. The punchline reveals that God is essentially running an "applied mathematics" operation, using evolving statistical models to optimize heavenly admissions. The comic satirizes both religious morality (reducing virtue to a checklist) and the modern obsession with algorithmic optimization, suggesting that even divine judgment might benefit from better data science -- or more absurdly, that Heaven has become a tech startup obsessed with improving its recruitment metrics.