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Explanation
This comic shows a figure (implied to be God) performing a standup comedy routine to an audience. The bit goes: "The longest lived creatures on earth are the least likely to be aware of their own mortality. Most choices affecting our life of an individual occurred before the individual was born. Because emotional states are produced by relative experience, not objective measurements, all of this is the ultimate source of all sadness."
The caption reads: "God's standup routine was unpopular, but it sure made Him laugh."
The joke operates on the concept of cosmic humor -- truths that are funny from a God's-eye perspective but deeply depressing from a human one. The observations in God's "routine" are all philosophically accurate: organisms like trees and tortoises that live the longest have minimal self-awareness; the circumstances of your birth (country, family, genetics) shape your life more than your own choices; and hedonic adaptation means that happiness is relative, not absolute, making lasting contentment impossible. These facts are "funny" only if you're an omniscient being looking down at the absurdity of the human condition. For the human audience, they're just bleak existential truths. The image of God doing standup and laughing at His own jokes while the audience sits in uncomfortable silence perfectly captures the idea that the universe might have a sense of humor, but it's not one we enjoy.