ie
Explanation
This comic explains the Latin abbreviation "i.e." A character states "Oh that, it's an abbreviation for 'id est,' which means 'now that I've made my argument in a confusing way, here's the same idea but with clarity.'"
The joke is that this is simultaneously wrong (as a literal translation of the Latin) and completely right (as a description of how "i.e." is actually used in practice). People typically deploy "i.e." after they've already stated something in a convoluted or jargon-heavy way and want to rephrase it more simply. The comic cuts through the pretension of using Latin abbreviations by pointing out that "i.e." is essentially an admission that your first attempt at explaining something was unclear.
The bonus fun fact at the bottom -- "You can learn Latin just by reading scientific manuscripts" -- adds another layer, poking fun at how academic writing is littered with Latin phrases (i.e., id est, e.g., et cetera, et al., etc.) to the point where a reader picks up a smattering of Latin almost by osmosis. It satirizes academic writing culture's reliance on Latin as a marker of erudition when plain language would often serve better.