morality
Explanation
This comic is a philosophical dialogue about the problem of human morality and cosmic-scale thinking.
In the first panel, God addresses a blue-haired character: "God, how is it that you're all so good and well-meaning, but the world is bad?" The response begins: "Because human morality is a kludge built on brains that only evolved for chewing and hunting."
The second panel escalates: "Here, watch. I'll make you a deal. You read all of cosmology, and try to make the universe so perfectly in such a way that it has no bearing on the present." This challenges the idea that understanding the grand scale of the universe should rationally influence human moral behavior -- but it doesn't, because our brains weren't built for that scale.
The third panel drives the point further, noting that humans can't hold more than a few objects in short-term memory at a time, yet we're expected to have informed opinions about the management of the cosmos. The humor comes from the absurd mismatch between human cognitive limitations and the scale of moral questions we face.
The fourth panel reaches the philosophical crescendo: "You can't even solve the collective action problem -- that is, you can't even get people to cooperate at small scales on the rules governing the behavior of living systems." This points out that humanity can't solve basic coordination problems, let alone cosmic-scale moral ones.
The final panels deliver the punchline: "I'm starting to think the existence of sapience was an assumption too many." The response: "Sounds like someone's looking for punishment for those kids." The joke is that God essentially admits creating beings intelligent enough to perceive moral problems but too cognitively limited to solve them was a design error -- and rather than fix the design, God defaults to punishment, which is itself a very human (and very limited) moral response. The comic satirizes both human moral limitations and the theological problem of evil.