mucho
Explanation
The Joke
A man is boasting about all the useless trivia he has accumulated: he can name more fad diets than philosophers, more Simpsons episodes than poems, more rules of plumber types than Shakespeare sonnets, more porn star names than Roman gods, and more reality TV beauty contestants than planned economies. In other words, he is deeply versed in pop culture and modern minutiae but almost entirely ignorant of history, literature, and high culture.
When confronted with "That's fine, or, may I have nachos, then?" -- suggesting the other person doesn't care about the boasting -- the man insists "There is no other choice! We should never stop! Never change! Never read! Never learn! Never save anything new!" The final panel reveals that this rant is being delivered to an audience, and the audience member responds with "Grande Americano, please" -- indicating the speaker is actually just a barista at a coffee shop holding up the line with his existential tirade.
The Humor
The comic satirizes anti-intellectual pride -- the phenomenon where people boast about their ignorance of "serious" subjects as if it were a badge of honor. The escalating list of pop-culture-versus-high-culture comparisons builds the absurdity, and the punchline deflates the grandiosity by revealing the speaker is in a completely mundane service job, ranting at customers who just want their coffee. The joke works on multiple levels: it mocks both the performative anti-intellectualism and the misplaced self-importance of someone who turns a minor personality trait into a philosophical manifesto.
References
The comic references several cultural touchstones including The Simpsons, Shakespeare's sonnets, and Roman mythology as stand-ins for "things one ought to know." The term "planned economies" is a nod to socialist/communist economic systems, contrasted absurdly with reality TV knowledge.