On
Explanation
The Joke
A woman is running a program for "unknown reasons" and tells her partner to "better turn me off and on." Her partner responds with a suggestive aside: "May does that work, though? You don't just turn yourself off. You turn me off and on too. But seriously, let's not discuss us being turned on." The woman cuts him off, saying something like "Look, that's a mystery. Let's talk about it. Is there an ordinary off and on button we're missing?"
The comic plays on the double meaning of "turn me off and on" -- the technical sense of power-cycling a device to fix it (a classic IT troubleshooting step) and the sexual/romantic sense of being "turned on" or "turned off" by someone. The characters stumble through the conversation as the sexual innuendo keeps accidentally emerging from what is meant to be a purely technical discussion.
In the final panel, the concept of "off and on buttons" is discussed, with one character saying "that explains so much," suggesting that understanding human on/off switches would indeed clarify a great deal about relationships.
The Humor
The humor derives from the inescapable double entendre embedded in basic computing terminology. "Turning off and on" is the most fundamental troubleshooting advice in technology, but in the context of a conversation between romantic partners, every mention of being "turned on" or "turned off" carries sexual overtones. The characters' attempts to navigate the conversation while avoiding the innuendo only make it worse, creating an escalating comedy of awkwardness. The comic highlights how much everyday technical language overlaps with sexual language in ways we normally ignore.