point
Explanation
The comic opens with one character saying "Dude, it's like, pointless," to which the other replies "Of course not." The first character then elaborates that there are a small number of wealthy, powerful people who shape history, and asks how their dedication to science or literature could ever make a difference. The second character pivots and says "I mean, yours is" -- meaning "your life is pointless," but not for the grand philosophical reasons the first person was suggesting.
The humor hinges on a classic misdirection. The first character is engaged in a familiar existential complaint -- the idea that ordinary people's efforts are meaningless compared to the outsized influence of the rich and powerful. The audience expects the second character to either agree with this nihilistic worldview or offer a rebuttal about the value of individual effort. Instead, the second character agrees that the first character's life is pointless, but only as a personal insult rather than a philosophical statement. The joke reframes the existential crisis as a roast.
In the final panel, the second character adds something like "you're off the hook, baby, you don't have to save the universe" -- turning the insult into a kind of backhanded comfort. The comic satirizes the tendency to dress up personal laziness or mediocrity in grand philosophical language. Sometimes the reason your contributions don't matter isn't because of systemic power imbalances -- it's just you.