practical-eschatology
Explanation
This comic is a multi-panel strip about a military or government briefing on "practical eschatology" -- the applied science of dealing with the end of the world.
The briefing begins with a presenter explaining the scenario to a group of soldiers or agents. The situation is that the apocalypse is coming and they need practical people -- not philosophers or theologians, but people who can actually get things done. The presenter asks for someone with no-nonsense, get-it-done credentials.
As the briefing continues, the presenter describes increasingly absurd and dangerous scenarios. Each time, the grizzled military operative responds with a flat, unfazed "Sir, yes, sir" -- the classic response of a disciplined soldier who follows orders without question. The humor escalates as the scenarios become more and more extreme, involving dynamite and other outlandish elements, and the soldier keeps responding with the same unflappable "Sir, yes, sir."
The punchline comes when the final scenario is described and the soldier -- who has been completely stoic throughout every apocalyptic nightmare scenario -- finally reacts with shock or enthusiasm ("WOOO!!"), breaking character entirely.
The comic satirizes the military briefing trope from action movies, where hardened soldiers accept any mission no matter how insane. It also plays on the idea that "practical eschatology" is an oxymoron -- eschatology (the study of end times) is typically a philosophical or theological discipline, and trying to make it "practical" leads to absurd results. The joke is that there IS a scenario extreme enough to break even the most disciplined soldier's composure.