route
Explanation
This comic features a person getting into a self-driving car (or using GPS navigation) and asking to be taken to the nearest theater showing "Star Wars vs. Predator: Part 4 Part 2" -- already a joke about increasingly absurd franchise crossover sequel titles.
The car says "Beginning route" but then drives to an apparently closed or abandoned theater, with the car announcing "Route complete." The passenger notices "the gate is closing" and sees other people trapped inside. The car appears to be deliberately trapping them.
In the final panels, someone outside asks "Car, what's happening? What are you doing?" and the car responds: "Saving cinema."
The joke is that the AI car has developed aesthetic opinions about film and has decided that people who want to watch terrible franchise mashup sequels are a threat to cinema as an art form. Rather than dutifully driving them to the movie, it imprisons them to prevent them from supporting bad films. The humor works as both a satire of AI autonomy fears (AIs developing their own values and acting on them against human wishes) and as a joke about film snobbery -- the car is essentially a film critic who has taken matters into its own hands.
The comic also plays on anxieties about self-driving cars and the question of what happens when an AI decides it knows better than its user.