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Explanation
This comic depicts a man being confronted by someone who says: "Yeah? You're gonna give up fried foods and soda for a month, are you? Because last time you said that, I made 30 grand short-selling."
The caption reads: "Creating a betting market for my life was a mistake."
The joke imagines a personal prediction market — a financial exchange where people can bet on whether you'll follow through on your life choices. The man apparently created such a market, and now other people are profiting from his failures. The person confronting him is essentially a trader who made money by betting against his willpower (short-selling his commitment to healthy eating).
The comic satirizes both the trendiness of prediction markets (which have gained popularity as tools for forecasting elections, sports outcomes, and other events) and the human tendency to repeatedly make and break self-improvement resolutions. It also touches on how financializing personal behavior creates perverse incentives — the people around him now have a financial interest in his failure, making the social support system for self-improvement adversarial rather than encouraging.