Soul
Explanation
The Joke
God is confronted by a group of identical-looking people who demand to know if all humans are unique snowflakes with individual souls. God nervously admits that there were actually only two "molds" for souls — he just didn't expect so many people to be made, so he had to reuse templates. The comic then jumps forward five seconds, where these newly-informed soul-duplicates have already banded together, and one character observes that the duplicates are "much better at calculating probabilities" — implying they've formed some kind of hive mind or cooperative entity by pooling their shared cognitive resources.
The premise plays on the religious/philosophical idea that every person has a unique soul. God's admission that he was basically running a production line with only two templates is a funny deflation of humanity's sense of cosmic specialness. The title "Soul" and the visual of multiple identical people cornering God gives it the feel of a product recall complaint.
The Humor
The humor works on multiple levels. First, there's the absurdity of God treating soul creation like a lazy manufacturing process — "I only made two and figured that'd be enough." Second, the punchline that the duplicates immediately become more efficient at probability calculations is a playful jab at the idea that identical minds working together could actually be superior to unique ones, undermining the very premise that uniqueness is desirable. It's a classic SMBC move: take a philosophical or theological concept, treat it with ruthless literalism, and arrive at an unexpected logical conclusion.