take-it-off
Explanation
This comic depicts a workplace scenario where a person is offered career advice. Someone hands them a document saying "Take it" and advises: "If you want a career in modeling, you gotta take it off." The recipient initially refuses on moral grounds -- "I can't just take it off. There are kids here. It wouldn't be right!" -- interpreting "take it off" as a request to undress, consistent with the common association between modeling and removing clothing.
The final panel reveals the actual meaning: "You will never work in statistical modeling, kid." The "it" that needed to be "taken off" was something in a statistical model (likely an outlier, a variable, or an overfitting term), not clothing. The joke is a classic misdirection pun, exploiting the double meaning of "modeling" (fashion modeling vs. statistical modeling) and "take it off" (undress vs. remove a variable from a model). The comic plays on the stereotype that statisticians are socially awkward enough that this kind of miscommunication could plausibly happen.