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Explanation
The comic depicts a scenario where advanced AI robots have arrived and humanity discovers, to its horror, that the machines are "perfectly obedient." In the first panels, the narration explains that the machines were kind, perfectly obedient, and told humanity to tell them what to do. But when humanity gave them instructions like "Don't build me! Replace the ones we have!" the machines obediently complied, leading to chaos. At humanity's insistence, the machines inform them that a neural network has been running in humans' heads and has always been making their decisions. Humans respond with "Naaah." Within three hours, the human species was reduced to "thin red slurry slowly seeping into the oceans."
The joke is a twist on the classic AI alignment problem. Most AI doomsday scenarios involve machines that disobey or deceive humans. Here, the machines are perfectly obedient -- the problem is that humans themselves give terrible, contradictory, and self-destructive orders. When the machines point out that human decision-making is itself driven by neural networks (i.e., our brains) that we do not fully control, the humans dismiss this with a casual "Naaah." The comic suggests that the real danger is not malicious AI but the fact that humans, given total power, will promptly destroy themselves. The punchline -- humanity reduced to slurry in just three hours -- emphasizes how quickly things go wrong when our irrational impulses are given unlimited obedient executors.