Women
Explanation
The Joke
A father tells his son: "Son, I want to give you this," and hands him a book titled "What Women Want." The son is taken aback, but the father clarifies: "Dad, come on. Women aren't a monolith. They can't be reduced to a single list of desires encompassed in a single book." The father responds: "It's not a real book. Open the cover." The implication is that inside the book there is a message -- perhaps something along the lines of "ask them" or "they're all different" -- that confirms exactly what the son just said.
In the final panel, a bored-looking person at a store counter says "Trust me son, trust me" -- suggesting this is actually a commercially available novelty book, and the father bought it as a kind of gag gift whose entire purpose is to deliver the lesson the son already articulated.
The Humor
The comic sets up what appears to be a cliched father-son moment where outdated gender wisdom will be passed down, then subverts it twice. First, the son pushes back with a perfectly reasonable modern objection about not reducing women to a monolith. Then the father reveals that the "book" itself is apparently a prop that delivers the same message -- making the son's earnest objection somewhat redundant and deflating. The humor lies in the awkward irony: the son's woke objection was exactly what the gag book was going to say, meaning the father was already ahead of him. The final panel's "Trust me" from what appears to be a bookstore employee adds an additional layer, suggesting this scenario plays out with every father-son pair who encounters this novelty item.