Worst
Explanation
The Joke
Two men are at a bar, and one advises the other: "Dude, just ask her out. The worst thing she can do to you is say no." This is the classic pep talk given to someone who is nervous about approaching a potential romantic interest -- the reassurance that rejection is the worst possible outcome, and rejection is survivable.
The man takes the advice, approaches the woman, and says: "Hi there. Can I buy you a--" but she interrupts him by excitedly saying: "Return of the Jedi isn't as good as you remember!" This is not a rejection in the traditional sense, but something arguably worse: an unsolicited, devastating opinion about a beloved Star Wars film.
In the final panel, the man returns to his friend, shouting "YOU LIED! YOU LIED!" -- because saying "no" was NOT the worst thing she could do. Attacking his cherished childhood memories of Return of the Jedi was far more painful than simple romantic rejection.
The Humor
The comic subverts the well-known reassurance "the worst she can say is no" by presenting an outcome that is technically not rejection but is emotionally far more devastating to a certain type of person (i.e., a Star Wars fan). The humor works because it plays on nerd culture's intense attachment to beloved franchises. For many people, being told that a foundational movie of their childhood "isn't as good as you remember" is a deeper wound than romantic rejection.
The joke also works because the woman's response is so completely non sequitur -- she does not even acknowledge his attempt to buy her a drink, instead launching into an unprompted hot take about Star Wars. This absurd conversational mismatch amplifies the comedy.
References
Return of the Jedi (1983) is the third film in the original Star Wars trilogy. It is often considered the weakest of the original three films by critics, with common complaints about the Ewoks and a rehashed Death Star plot. However, it remains beloved by many fans who grew up with it. The debate over its quality is a perennial topic in fan communities, making the woman's statement a particularly well-chosen barb.