Wow!
Explanation
This comic riffs on the idea of humanity's insignificance in the cosmos -- and then undercuts it.
A man prays to God, saying "Dear God..." God responds with enthusiasm: "Holy crap! Humans are still around!" He is genuinely surprised and delighted that humanity still exists, which implies that from God's cosmic perspective, humans are a minor and easily forgotten species.
God then reveals that he had been distracted: he "restructured the universe" and left some loose ends, assuming "you know, the usual" would take care of things -- perhaps implying he expected humanity to go extinct through one of the usual apocalyptic means (nuclear war, climate change, asteroid impact, etc.). He mentions "a couple of those weapons" in a way that suggests he scattered existential threats around casually.
The comic then shifts tone. The man on Earth, rather than being humbled by God's indifference, is excited: "Wow! I'm gonna write about this!" His companion tries to temper expectations: "Maybe wait to tell people -- it might not be that amazing." But the first man insists: "Wait till I tell the world about this amazing experience!"
The joke operates on multiple levels. First, there is the cosmic horror of learning that God basically forgot about humanity. Second, there is the satirical observation that humans will take even the most disturbing revelations and spin them into content -- the man's first instinct upon learning that God nearly let humanity go extinct is not existential dread but excitement about having a good story to tell. It parodies how people treat encounters with the sublime as social media fodder rather than genuinely reckoning with their implications.