yup
Explanation
This comic riffs on the Fermi Paradox -- the question of why, given the vast size and age of the universe, we have not detected any signs of extraterrestrial intelligence.
The comic opens with a man lying on the grass at night, stargazing. He asks an alien visitor whether, upon encountering humanity, the aliens are going to tell humans all the secrets of the cosmos. The alien replies "Yup. 100%." The man then asks how it all works: the alien explains that life started early, the Earth cooled, there are billions of Earth-like planets in the galaxy, and technological growth is exponential, so any sufficiently advanced civilization inevitably produces artificial life. The punchline comes when the alien reveals that such civilizations broadcast a signal so globally and so incessantly -- essentially the cosmic equivalent of spam or annoying content -- that every other civilization in the universe picks it up, gets bored, and deliberately ignores it.
The humor lies in the deflation of cosmic grandeur. Instead of the Fermi Paradox being explained by something profound (civilizations destroying themselves, the zoo hypothesis, the dark forest theory), the answer is hilariously mundane: alien civilizations are basically producing the equivalent of obnoxious social media content or broadcast spam, and everyone else just tunes them out. It is a satirical commentary on modern media culture -- the idea that even on a galactic scale, the dominant form of communication would be irritating, low-quality content that nobody wants to engage with.
The final panel shows the alien in its ship, calling the man a "progenitor" with visible disdain, implying that humanity is on the path to becoming yet another one of these annoying broadcasting civilizations. The alien's use of "Don't even remind me" suggests weary familiarity with this pattern repeating across the cosmos.