Whisk
Explanation
This comic is a chart-style joke about the various spellings of "whiskey" (or "whisky") and when each is used -- starting with real distinctions and escalating into absurdity.
The first two rows are factually accurate: "Whiskey" (with an 'e') is the spelling used in the United States and Ireland, while "Whisky" (without the 'e') is used everywhere else, notably Scotland, Canada, and Japan.
From there, the chart spirals into increasingly ridiculous variations. "Hwisky" is used "whenever drunkenly pretending to know what Old English sounds like." "Hwisky" appears again for use in the USA or Ireland. "Uisci" is listed as "used by ancient druids and Dungeons & Dragons players" -- a reference to the actual Gaelic origin word "uisce beatha" (water of life). "Whiskeyyyyyyyyyy" is for "asking for your fourth whiskey." "Whiski" is used "when under the impression 'Whiski' is the Russian spelling." "Hwiskyyyyyyy" is for asking for your fourth hwisky. And finally, "Bourbon" has "all letters silent except for R, which is pronounced 'whiskey'" -- a joke suggesting that bourbon is really just whiskey by another name, delivered through an absurd phonetic claim.
The comic parodies the genuine pedantry around whiskey/whisky spelling conventions by extending that pedantry to its logical extreme, suggesting that the entire system of spelling variations is arbitrary and silly.